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The Effect of PDE5 Inhibitors on the Male Reproductive Tract

Author(s):

Nikolaos Sofikitis*, Aris Kaltsas, Fotios Dimitriadis, Jens Rassweiler, Nikolaos Grivas, Athanasios Zachariou, Apostolos Kaponis, Panagiota Tsounapi, Napoleon Paterakis, Andreas Karagiannis, Sotirios Skouros, Ioannis Giannakis, Ioannis Champilomatis, Minas Paschopoulos, Diamantis Daphnis, Ioannis Giakoumakis, Melinda R. Gabales, Jo Ben M. Chua, Pedro L. Lantin III, Charalampos Mamoulakis and Atsushi Takenaka   Pages 1 - 17 ( 17 )

Abstract:


The therapeutic range of cyclic nucleotide phosphodiesterase 5 inhibitors (PDE5) inhibitors is getting wider in the last years. This review study focuses on the potential employment of PDE5 inhibitors as an adjunct tool for the therapeutic management of male infertility. The literature tends to suggest a beneficial effect of PDE5 inhibitors on Leydig and Sertoli cells secretory function. It also appears that PDE5 inhibitors play a role in the regulation of the contractility of the testicular tunica albuginea and the epididymis. Moreover scientific data suggest that PDE5 inhibitors enhance the prostatic secretory function leading to an improvement in sperm motility. Other studies additionally demonstrate a role of PDE5 inhibitors in the regulation of sperm capacitation process. Placebo-controlled, randomized, blind studies are necessary to unambiguously incorporate PDE5 inhibitors as an adjunct tool for the pharmaceutical treatment of semen disorders and male infertility.

Keywords:

Spermatozoa, testis, Epididymis, Phosphodiesterase

Affiliation:

Department of Urology, Ioannina University School of Medicine, Ioannina, Department of Urology, Ioannina University School of Medicine, Ioannina, 1st Department of Urology, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Department of Urology, University of Heidelberg, SLK Kliniken, Heilbronn, Department of Urology, Hatzikosta General Hospital, Ioannina, Department of Urology, Ioannina University School of Medicine, Ioannina, Department of Urology, Ioannina University School of Medicine, Ioannina, Department of Urology, Tottori University Faculty of Medicine, Yonago, Tottori, Ygeia Medical Center, Manila, Department of Urology, Ioannina University School of Medicine, Ioannina, Department of Urology, Ioannina University School of Medicine, Ioannina, Department of Urology, Ioannina University School of Medicine, Ioannina, Department of Urology, Ioannina University School of Medicine, Ioannina, Department of Obstetrics and Gynecology, Ioannina University School of Medicine, Ioannina, Mediterranean Fertility Center, Chania, Mediterranean Fertility Center, Chania, East Avenue Medical Center, Diliman, Quezon City, East Avenue Medical Center, Diliman, Quezon City, East Avenue Medical Center, Diliman, Quezon City, Department of Urology, University of Crete Medical School, Heraklion, Crete, Department of Urology, Tottori University Faculty of Medicine, Yonago, Tottori



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