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Recent Nano-based Therapeutic Intervention of Bioactive Sesquiterpenes: Prospects in Cancer Therapeutics

[ Vol. 26 , Issue. 11 ]

Author(s):

Mohammad A. Ansari*, Khan F. Badrealam, Asrar Alam, Saba Tufail, Gulshan Khalique, Mohammad J. Equbal*, Mohammad A. Alzohairy, Ahmad Almatroudi, Mohammad N. Alomary and Faheem H. Pottoo   Pages 1138 - 1144 ( 7 )

Abstract:


In the recent scenario, nanotechnology-based therapeutics intervention has gained tremendous impetus all across the globe. Nano-based pharmacological intervention of various bioactive compounds has been explored on an increasing scale. Sesquiterpenes are major constituents of essential oils (EOs) present in various plant species which possess intriguing therapeutic potentials. However, owing to their poor physicochemical properties; they have pharmacological limitations. Recent advances in nano-based therapeutic interventions offer various avenues to improve their therapeutic applicability. Reckoning with these, the present review collates various nano-based therapeutic intervention of sesquiterpenes with prospective potential against various debilitating diseases especially cancer. In our viewpoint, considering the burgeoning advancement in the field of nanomedicine; in the near future, the clinical applicability of these nano-formulated sesquiterpenes can be foreseen with great enthusiasm.

Keywords:

Sesquiterpenes, nanoformulations, cancer, therapeutics, Nano-based pharmacological intervention, essential oils.

Affiliation:

Department of Epidemic Disease Research, Institutes for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1881, Dammam 31441, Dairy Cattle Physiology Division, ICAR-National Dairy Research Institute, Karnal, Haryana-132001, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, Biochemistry Section, Women's College, Aligarh Muslim University, Aligarh, Uttar Pradesh-202002, School of Sciences, Jain University, Jayanagar, 3rd block, Bengaluru, Karnataka-560041, Biomedical Institute for Regenerative Research (BIRR), Texas A&M University-Commerce, Commerce, Texas-75429, Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Qassim 51431, Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Qassim 51431, National Center for Biotechnology, Life Science and Environmental Research Institute, King Abdulaziz City for Science and Technology, Riyadh, Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O Box 1881, Dammam, 31441



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