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Role of Prostaglandins in Multiple Sclerosis

[ Vol. 26 , Issue. 7 ]

Author(s):

Surendra Gulla, Dakshayani Lomada, Anusha Lade, Reddanna Pallu and Madhava C. Reddy*   Pages 730 - 742 ( 13 )

Abstract:


Multiple sclerosis (MS) is an autoimmune demyelinating disorder with chronic inflammation in the central nervous system, manifested by both physical and cognitive disability. Neuroinflammation and neurodegeneration are the phenomena that appear in the central nervous system associated with various neurodegenerative disorders, including MS, Alzheimer’s diseases, amyotrophic lateral sclerosis and Parkinson’s disease. Prostaglandins are one of the major mediators of inflammation that exhibit an important function in enhancing neuroinflammatory and neurodegenerative processes. These mediators would help understand the pathophysiology of MS as the combination of antagonists or agonists of prostaglandins receptors could be beneficial during the treatment of MS. The present review focuses on the role played by different prostaglandins and the enzymes which produced them in the etiopathogenesis of MS.

Keywords:

Multiple sclerosis, prostaglandins, cyclooxygenase, central nervous system, inflammation, prostaglandins.

Affiliation:

Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, AP 516 005, Department of Genetics and Genomics, Yogi Vemana University, Kadapa, AP 516 00, Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, AP 516 005, Department of Animal Biology, Hyderabad Central University, Hyderabad 500 046, Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, AP 516 005



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