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Energy-Sensing Pathways in Ischemia: The Counterbalance Between AMPK and mTORC

[ Vol. 25 , Issue. 45 ]

Author(s):

Angel Cespedes, Mario Villa, Irene Benito-Cuesta*, Maria J. Perez-Alvarez , Lara Ordoñez and Francisco Wandosell*   Pages 4763 - 4770 ( 8 )

Abstract:


Stroke is an important cause of death and disability, and it is the second leading cause of death worldwide. In humans, middle cerebral artery occlusion (MCAO) is the most common cause of ischemic stroke. The damage occurs due to the lack of nutrients and oxygen contributed by the blood flow.

The present review aims to analyze to what extent the lack of each of the elements of the system leads to damage and which mechanisms are unaffected by this deficiency. We believe that the specific analysis of the effect of lack of each component could lead to the emergence of new therapeutic targets for this important brain pathology.

Keywords:

Stroke, Middle Cerebral Artery Occlusion (MCAO), nutrients deprivation, Oxygen-glucose Deprivation (OGD), signaling, mTORC1, AMPK.

Affiliation:

Centro de Biología Molecular “Severo Ochoa”. CSIC-UAM. Nicolás Cabrera 1, 28049 Madrid, Centro de Biología Molecular “Severo Ochoa”. CSIC-UAM. Nicolás Cabrera 1, 28049 Madrid, Centro de Biología Molecular “Severo Ochoa”. CSIC-UAM. Nicolás Cabrera 1, 28049 Madrid, Centro de Biología Molecular “Severo Ochoa”. CSIC-UAM. Nicolás Cabrera 1, 28049 Madrid, Centro de Biología Molecular “Severo Ochoa”. CSIC-UAM. Nicolás Cabrera 1, 28049 Madrid, Centro de Biología Molecular “Severo Ochoa”. CSIC-UAM. Nicolás Cabrera 1, 28049 Madrid



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