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Biocompatible Polymers and their Potential Biomedical Applications: A Review

[ Vol. 25 , Issue. 34 ]

Author(s):

Uzma Arif, Sajjad Haider, Adnan Haider*, Naeem Khan*, Abdulaziz A. Alghyamah, Nargis Jamila, Muhammad Imran Khan, Waheed A. Almasry and Inn-Kyu Kang   Pages 3608 - 3619 ( 12 )

Abstract:


Background: Biocompatible polymers are gaining great interest in the field of biomedical applications. The term biocompatibility refers to the suitability of a polymer to body and body fluids exposure. Biocompatible polymers are both synthetic (man-made) and natural and aid in the close vicinity of a living system or work in intimacy with living cells. These are used to gauge, treat, boost, or substitute any tissue, organ or function of the body. A biocompatible polymer improves body functions without altering its normal functioning and triggering allergies or other side effects. It encompasses advances in tissue culture, tissue scaffolds, implantation, artificial grafts, wound fabrication, controlled drug delivery, bone filler material, etc.

Objectives: This review provides an insight into the remarkable contribution made by some well-known biopolymers such as polylactic-co-glycolic acid, poly(ε-caprolactone) (PCL), polyLactic Acid, poly(3- hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), Chitosan and Cellulose in the therapeutic measure for many biomedical applications.

Methods: Various techniques and methods have made biopolymers more significant in the biomedical fields such as augmentation (replaced petroleum based polymers), film processing, injection modeling, blow molding techniques, controlled / implantable drug delivery devices, biological grafting, nano technology, tissue engineering etc.

Results: The fore mentioned techniques and other advanced techniques have resulted in improved biocompatibility, nontoxicity, renewability, mild processing conditions, health condition, reduced immunological reactions and minimized side effects that would occur if synthetic polymers are used in a host cell.

Conclusion: Biopolymers have brought effective and attainable targets in pharmaceutics and therapeutics. There are huge numbers of biopolymers reported in the literature that has been used effectively and extensively.

Keywords:

Biopolymers, scaffolds, drug delivery, tissue engineering, nano technology, biocompatibility.

Affiliation:

Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Department of Chemical Engineering, College of Engineering, King Saud University, Riyadh, Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Department of Chemical Engineering, College of Engineering, King Saud University, Riyadh, Department of Chemistry, Shaheed Benazir Bhutto Women University, Peshawar, KPK, Deparment of Pharmacy, Kohat University of Science and Technology, Kohat KPK, Department of Chemical Engineering, College of Engineering, King Saud University, Riyadh, Department of Polymer Science and Engineering, Kyungpook National University, Daegu



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