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Recent advances in high-throughput platforms with engineered biomaterial microarrays for screening of cell and tissue behavior

Author(s):

Jungmok Seo, Yeontaek Lee and Jungmok Seo*  

Abstract:


For the last decades, bioengineers have developed myriad biomaterials for the regenerative medicine. Developments of screening techniques is essential in understanding complex behavior of cells in the biological microenvironments. Conventional approaches to screening of cellular behavior in vitro have limitations in terms of accuracy, reusability, labor-intensive screening, and versatility. Thus, drug screening and toxicology test through in vitro screening platforms have been underwhelming. Recent advances in the high-throughput screening platforms somewhat overcomes the limitations of in vitro screening platforms via repopulating human tissues’ biophysical and biomchemical microenvironments with the ability to continual monitoring of miniaturized human tissue behavior. Herein, we review current trends in screening platform in which high-throughput system composed of engineered microarray devices is developed to investigate cell-biomaterial interaction. Furthermore, diverse methods to achieve continual monitoring of cell behavior via developments of biosensor integrated high-throughput platforms, and future perspectives on high-throughput screening will be provided.

Keywords:

High-throughput platforms, Cell-biomaterial interactions, Cellular microenvironments, Biomaterial screening, Organs-on-a-chip

Affiliation:

School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of, School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of, School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of



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