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Pharmacokinetic Modeling in Nano-formulations: Concept, Implementation and Challenges

[ Vol. 24 , Issue. 43 ]

Author(s):

Jatinder Kaur Mukker and Ravi Shankar Prasad Singh*   Pages 5175 - 5180 ( 6 )

Abstract:


The properties of nanoparticles can be exploited to overcome challenges in drug delivery. By virtue of its design and size, the pharmacokinetics of nanoparticles are different than other small molecules. Modeling and simulation techniques have great potential to be used in nanoformulation development; however, their use in optimization of nanoformulation is very limited. This review highlights the differences in absorption, distribution, metabolism and excretion (ADME) characteristics of nanoparticles, use of modeling and simulation techniques in nanoformulation development and challenges in the implementation of modeling techniques.

Keywords:

Nanoparticles, pharmacokinetics, modeling and simulations, PBPK modeling, microdialysis, drug delivery.

Affiliation:

Translational Medicine & Clinical Pharmacology, Boehringer-Ingelheim Pharmaceutical, Inc. Ridgefield, CT 06877, Clinical Pharmacology, Early Clinical Development, Pfizer, Inc., Cambridge, MA 02139



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