Giuseppe Coppolino*, Giuseppe Leonardi, Michele Andreucci and Davide Bolignano Pages 1 - 6 ( 6 )
Background: ROS are highly reactive and cause in single cells: protein alteration, DNA damage, cellular senescence and apoptosis; while the effect of ROS in biological tissues leads to a harmful oxidation effect on all their biochemical components: lipids, proteins, carbohydrates, and nucleic acids. Oxidative stress plays a role in the pathophysiology of renal impairment and is a mediator of CKD progression; furthermore during substitutive therapy with haemodialysis or peritoneal dialysis and in case of transplantation, organism continues to be exposed to oxidation causing the development of major systemic comorbidities in particular cardiovascular diseases. Methods: In this review, we summarized some information regarding the link between the kidneys and oxidative stress. The kidneys maintain plasma homeostasis by filtering plasma and reabsorbing approximately 99% of the filtrate back into the plasma. This enormous reabsorption work requires a great consumption of molecular oxygen (O2) due to active transport. Conclusion: Accruing evidences indicated the kidney as a fundamental organ in reactive oxygen species (ROS) production.
Oxidative stress, renal function, Chronic Kidney Disease (CKD)
Nephrology and Dialysis Unit; “Pugliese-Ciaccio” General Hospital, 88100 Catanzaro, Department of Health Sciences, Magna Graecia University, Viale Europa, Localita' Germaneto 88100 , Catanzaro, Department of Health Sciences, Magna Graecia University, Viale Europa, Localita' Germaneto 88100 , Catanzaro, Institute of Clinical Physiology, CNR - Italian National Council of Research, Via Vallone Petrara c/o Ospedali Riuniti, Reggio Calabria, Italy, 89100