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The Therapeutic Potential of Angiotensin-converting enzyme and angiotensin receptor inhibitors in the treatment of colorectal cancer: Rational Strategies and Recent Progress

Author(s):

Fereshteh Asgharzadeh, Seyed Mahdi Hassanian, Gordon A. Ferns, Majid Khazaei and Malihe Hasanzadeh*  

Abstract:


Colorectal cancer (CRC) is one of the most common causes of cancer-related death in the world. There is document that angiotensin (AT) is involved in the progression of CRC. Furthermore, Angiotensin receptor inhibitors (ARIs) and angiotensin-converting enzyme Inhibitors (ACE-Is) demonstrate activity in CRC by their inhibition of both Insulin-like growth factor 1 (IGF-1) and Vascular endothelial growth factor (VEGF), and therefore present a potentially novel therapeutic strategy in colorectal cancer, which have summarized in the current review. Preclinical studies have illustrated the direct effect of major active mediator angiotensin II (ATII) on the promotion of angiogenesis through VEGF and other proliferative mediators. Suppression of the angiotensin II type I receptor (AT1R) via ACE-Is has shown a reduction in the development of solid tumor and metastasis, particularly CRC incidence, polyp formation, and distant metastasis. MicroRNAs (miRs) are a family of small nucleotides without coding that play an important role in silence after transcribing hundreds to thousands of non-coding and coding gene. Against this background, the application of anti-hypertensive medications such as losartan might have a therapeutic impact, although further preclinical and clinical studies might provide novel insight into the potentially beneficial effect of ACE-Is in the treatment of colorectal cancer patients.

Keywords:

Colorectal cancer, Converting Enzyme Inhibitors, Angiotensin Receptor Inhibitors

Affiliation:

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Department of Gynecology Oncology, Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad



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