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MicroRNA-based Biosensors for Early Detection of Cancers

[ Vol. 24 , Issue. 39 ]

Author(s):

Majid Rezayi*, Zahra Farjami, Zeinab S. Hosseini, Neshat Ebrahimi and Ebrahim Abouzari-Lotf   Pages 4675 - 4680 ( 6 )

Abstract:


Small noncoding microRNAs (miRNAs) are known as noninvasive biomarkers for early detection in various cancers. In fact, miRNAs have key roles in carcinogenicity process such as proliferation, apoptosis and metastasis. After cardiovascular disease, cancer is the second cause of death in the world with an estimated 9.6 million deaths in 2018. So, early diagnosis of cancer is critical for successful treatment. To date, several selective and sensitive laboratory-based methods have been applied for the detection of circulating miRNA, but a simple, short assay time and low-cost method such as a biosensor method as an alternative approach to monitor cancer biomarker is required. In this review, we have highlighted recent advances in biosensors for circulating miRNA detection.

Keywords:

Biosensor, cancer, diagnosis, biomarker, miRNA, carcinogenicity.

Affiliation:

Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Student Research Committee, Faculty of Medicine, Islamic Azad University of Mashhad, Mashhad, Laboratory of Cedars-Sinai Medical Center, Los Angeles, California, Advanced Materials Research Group, Center of Hydrogen Energy, Institute of Future Energy, Universiti Teknologi Malaysia, 54100, Kuala Lumpur



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