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MicroRNA-based biosensors for early detection of cancers

Author(s):

Majid Rezayi*, Zahra Farjami, Zeinab Sadat Hosseini, Neshat Ebrahimi and Ebrahim Abouzari-Lotf  

Abstract:


Recently small noncoding microRNAs (miRNAs) are known as noninvasive biomarkers for early detection in various cancers. In fact, miRNAs have key roles in carcinogenicity process such as out of proliferation, block of apoptosis and metastasis. After cardiovascular disease, cancer is the second cause of death in the world which is estimated that around 9.6 million people death in 2018. So, early diagnosis of cancer is critical for their successful treatment. To date, several selective and sensitive laboratory-based methods have been applied for detection of circulating miRNA, but a simple, short assay time and low-cost method such as a biosensor method as an alternative approach to monitor the cancer’s biomarker is required. In this view, we have highlighted the recent advances biosensors for circulating miRNA detection.

Keywords:

Biosensor; Cancer; Diagnosis; Biomarker; miRNA

Affiliation:

Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Student Research Committee, Faculty of Medicine, Islamic Azad University of Mashhad, Mashhad, Laboratory of Cedars-Sinai Medical Center, Los Angeles, California, Advanced Materials Research Group, Center of Hydrogen Energy, Institute of Future Energy, Universiti Teknologi Malaysia, 54100, Kuala Lumpur



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