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miRNA targeting angiogenesis as a potential therapeutic approach in the treatment of colorectal cancers

Author(s):

Forouzan Amerizadeh, Majid Khazaei, Mona Maftouh, Ramin Mardani and Afsane Bahrami*  

Abstract:


Angiogenesis refers to the formation of recent blood vessels, which is one of the characteristics of cancer progression. and it has been deliberated a putative target to the treatment of many kinds of cancers. The VEGF signaling substrate is very important for angiogenesis and is commonly high-regulated in tumors. As a result, this molecule has attracted one of the most attention of researchers to develop antiangiogenic therapies. We have presented that VEGF blockage in neoadjuvant setting via bevacizumab, aflibercept and sunitinib not only have revealed some promising benefit but also it shows a large negative outcome in the adjuvant trials. However, in some advanced stage of tumors, suppression of VEGF alone is inadequate to stop advancement, encourages to drug resistance, and probably enhances metastasis and invasion in the tumor microenvironment, suggesting the therapeutic potential of targeting angiogenic pathways in gastrointestinal cancers.

Keywords:

angiogenesis, vascular endothelial growth factor, bevacizumab

Affiliation:

Department of Modern Sciences and Technologies; Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand



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