Mona Fani, Milad Zandi, Majid Rezayi, Nastaran Khodadad, Hadis Langari and Iraj S Amiri*
MicroRNAs (miRNAs) are non-coding RNAs with 19 to 24 nucleotides which are evolutionally conserved. MicroRNAs play a regulatory role in many cellular functions such as immune mechanisms, apoptosis, and tumorigenesis. The main function of miRNAs is the post-transcriptional regulation of gene expression via mRNA degradation or inhibition of translation. In fact, many of them act as an oncogene or tumor suppressor. These molecular structures participate in many physiological and pathological processes of the cell. Also virus can produce them for the developing of its pathogenic processes. It was initially thought that viruses without nuclear replication cycle such as Poxviridae and RNA viruses are not able to code miRNA, but recently it has been proven that RNA viruses can also produce miRNA. The aim of this articles is describtion of viral miRNAs biogenesis and the their effects on cellular and viral genes.
Function, miRNAs, Viral infection, Cancer.
Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Department of virology, school of public health, Tehran university of Medical Science, Tehran, Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Computational Optics Research Group, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City