Mohammed S. Algahtani, Abdul Aleem Mohammed and Javed Ahmad*
Three-dimensional printing (3DP) has a significant impact on organ transplant, cosmetic surgery, surgical planning, prosthetics and other medical fields. Recently, 3 DP attracted the attention as a promising method for the production of small-scale drug production. The knowledge expansion about the population differences in metabolism and genetics grow the need for personalised medicine substantially. In personalised medicine, the patient received a tailored dose and release profile based on his pharmacokinetics data. 3 DP is expected to be one of the leading solutions for the personalisation of the drug dispensing. This technology can fabricate a drug-device with complicated geometries and fillings to obtain the needed drug release profile. The extrusion-based 3 DP is the most explored method for investigating the feasibility of the technology to produce a novel dosage form with properties that are difficult to achieve using the conventional industrial methods. Extrusion-based 3 DP is divided into two techniques, the semi-solid extrusion (SSE) and the fused deposition modeling (FDM). This review aims to explain the extrusion principles behind the two techniques and to discuss their capabilities to fabricate novel dosage forms. The advantages and limitations were observed through the application of SSE and FDM for fabrication of drug dosage forms were discussed in this review. Further exploration and development are required to implement this technology in the healthcare frontline for more effective and personalised treatment.
3D printing, semisolid extrusion, fused deposition modeling, drug delivery, personalized medicine.
Department of Pharmaceutics, College of Pharmacy, Najran University, Department of Pharmaceutics, College of Pharmacy, Najran University, Department of Pharmaceutics, College of Pharmacy, Najran University