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Role of regulatory oncogenic or tumor suppressor miRNAs of PI3K/AKT signaling axis in the pathogenesis of colorectal cancer

Author(s):

Atena Soleimani, Farzad Rahmani, Gordon A Ferns, Mikhail Ryzhikov, Amir Avan and Seyed Mahdi Hassanian*  

Abstract:


Colorectal cancer (CRC) is the leading cause of cancer death worldwide and its incidence is increasing. In most patients with CRC, the PI3K/AKT signaling axis is over-activated. Regulatory oncogenic or tumor suppressor microRNAs (miRNAs) for PI3K/AKT signaling regulate cell proliferation, migration, invasion, angiogenesis, as well as resistance to chemo-/radio-therapy in colorectal cancer tumor tissues. Thus, regulatory miRNAs of PI3K/AKT/mTOR signaling represent novel biomarkers for new patient diagnosis and obtaining clinically invaluable information from post-treatment CRC patients for improving therapeutic strategies. This review summarizes the current knowledge of miRNAs’ regulatory roles of PI3K/AKT signaling in CRC pathogenesis.

Keywords:

PI3K/AKT signaling, MicroRNA, Colorectal cancer

Affiliation:

Department of Medical Biochemistry, faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, Division of Pulmonary and Critical Care Medicine, Washington University, School of Medicine, Saint Louis, MO, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad



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