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The prognostic and predictive value of microRNAs in patients with H. pylori-positive gastric cancer

Author(s):

Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Amir Avan, Maryam Ghandehari, Fatemeh Goldani and Seyed Mohammadreza Parizadeh*  

Abstract:


Gastric cancer (GC) has a high mortality rate with a poor 5-year survival. Helicobacter pylori (H. pylori) is present as part of the normal flora of stomach. It is found in the gastric mucosa of more than half of the world population. This bacterium is involved in developing H. pylori-induced GC due to the regulation of different micro ribonucleic acid (miRNA or miR). miRNAs are small noncoding RNAs and recognized as a prognostic biomarker for GC that may control gene expression. miRNAs may function as a tumor suppressors, or oncogenes. In this review, we have evaluated studies who have investigated the ectopic expression of miRNAs in the prognosis of H. pylori positive and negative GC.

Keywords:

gastric cancer, tissue miRNA, Helicobacter pylori.

Affiliation:

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad



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