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The Esophageal Cancer and the PI3K/AKT/mTOR signaling regulatory microRNAs; a novel marker for prognosis, and a possible target for immunotherapy

Author(s):

Seyed Alireza Javadinia, Soodabeh Shahidsales, Azar Fanipakdel, Asma Mostafapour, Mona Joudi-Mashhad, Gordon A. Ferns and Amir Avan*  

Abstract:


The Phosphatidylinositol 3-kinase/AKT/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) pathway has a critical regulatory role cell biology including translation, transcription, and autophagy. Dysregulation of this pathway is involved in the pathogenesis, development, and prognosis of esophageal cancer has been assessed in the recent years and its potential as a target in therapy. This report summarizes the current knowledge about PI3K/AKT/mTOR pathway and their cross talk with a focused on the value of targeting this pathway as a potential therapeutic target in treatment of esophageal cancer.

Keywords:

PI3K/AKT/mTOR pathway, microRNAs, esophageal cancer

Affiliation:

Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Department of Medical Education, Brighton and Sussex Medical School Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex , Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad



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