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Three-Dimensional (3-D) Printing Technology Exploited for the Fabrication of Drug Delivery Systems

Author(s):

Farrukh Zeeshan*, Thiagarajan Madheswaran, Manisha Pandey and Bapi Gorain   Pages 1 - 11 ( 11 )

Abstract:


Background: The conventional dosage forms cannot be administered to all patients because of inter-individual variability found among people of different race coupled with different metabolism and cultural necessities. Therefore, to address this global issue there is a growing focus on the development of novel drug delivery systems customised to individual needs. Three-dimensional (3-D) printed medicines are transforming the current pharmaceutical market as a potential alternative to conventional medicine.

Methods: The PubMed database and Google scholar were browsed by keywords of 3-D printing, drug delivery, and personalised medicine. The data about techniques employed in the manufacturing of 3-D printed medicines and the application of 3-D printing technology in the fabrication of individualised medicine were collected, analysed and discussed.

Results: Numerous techniques can fabricate 3-D printed medicines however, printing-based inkjet, nozzle-based deposition, and laser-based writing systems are the most popular. 3-D printing technology has been successfully employed in the fabrication of tablets, polypills, implants, solutions, nanoparticles, targeted and topical dug delivery. In addition, the approval of Spritam® containing levetiracetam by FDA as the primary 3-D printed drug product has boosted its importance. However, some drawbacks such as suitability of manufacturing techniques and the available excipients for 3-D printing need to be addressed to ensure simple, feasible, reliable and reproducible 3-D printed fabrication

Conclusion: 3-D printing is a revolutionary in pharmaceutical technology to cater the present and future needs of individualised medicines. Nonetheless, more investigations are required on its manufacturing aspects in terms cost effectiveness, reproducibility and bioequivalence.

Keywords:

3-D printing, drug delivery, personalised medicine, fused deposition modelling, direct-write, zip dose.

Affiliation:

Department of Pharmaceutical technology, School of Pharmacy, International Medical University (IMU), Kuala Lumpur-57000, Department of Pharmaceutical technology, School of Pharmacy, International Medical University (IMU), Kuala Lumpur-57000, Department of Pharmaceutical technology, School of Pharmacy, International Medical University (IMU), Kuala Lumpur-57000, School of Pharmacy, Faculty of Health and Medical Science, Taylor’s University, Selangor-47500



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