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Circulating Exosomes as Potential Biomarkers in Cardiovascular Disease

[ Vol. 24 , Issue. 37 ]

Author(s):

Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Maryam Ghandehari, Seyed Mohammad Reza Parizadeh, Seyed Mahdi Hassanian, Majid Rezayi, Majid Ghayour-Mobarhan, Gordon A. Ferns and Amir Avan*   Pages 4436 - 4444 ( 9 )

Abstract:


Cardiovascular disease (CVD) is the first leading cause of morbidity and mortality in developing and developed countries. Circulating exosomes have recently been identified as extracellular transporters, detectable in biological fluids. Exosomes have established a new era in diagnosing diseases, especially CVD. Determination of exosome profiles, e.g., miRNAs, for different health states such as myocardial injury still requires further studies. In this review, we will discuss the role of exosomes as a potential biomarker in CVD, with particular emphasis on recent advances in the methods to study exosomes, isolation, detection, and characterization.

Keywords:

Cardiovascular disease, morbidity, mortality, extracellular vesicle, exosome, biomarker.

Affiliation:

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad



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