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Nanotechnology as an emerging pathway for cancer therapy and diagnosis

Author(s):

Albeena Mahmood, Kavindra Kumar Kesari, Ismat Fatima, Mohd. Haris Siddiqui*, Qazi Mohammad Sajid Jamal, Salman Akhtar, Mohd. Kalim Ahmad Khan, Mohammad Amjad Kamal and Jamal M. Arif  

Abstract:


Background- The increasing rate of cancer in younger generation is an issue of concern in 21st century. It is highly concerned to know that the available methods of cancer therapy like, radiotherapy and chemotherapy have several side effects causing infertility and neuronal diseases. Radiotherapy is one of the main modalities for the treatment of cancer as we donĀ“t have any other reliable treatment methods till date. Now-a-days, nanotechnology have been introduced for cancer detection and diagnosis. Therefore, cancer nanotechnology is an interdisciplinary area of research in science, engineering, and medicine with broad applications in molecular imaging, molecular diagnosis, and targeted therapy. Nanotechnology have potential to solve one of the most challenging problems in medicine, and to eliminate cancer without harming normal body tissue. Nanotechnology has enabled the manipulation of the biological and physicochemical properties of nanomaterials to facilitate more efficient drug targeting and delivery. Objective-This review highlights the use of nanotechnology in cancer therapy and different types of nanoparticles for examples lipid nanoparticle, polymer-based nanoparticle, carbon-based nanoparticles, engineered nanoparticles used in cancer detection and diagnosis. Study also distinguish between classical treatment methods (Radio & chemotherapy) and nanotherapy with futuristic approach. Method- As a part of method, different types of nanoparticles were opted based on their size and compatibility used in cancer detection and diagnosis. This article mainly opted advance nanotherapy methods, based on most recent studies. Result and conclusion- Nanotechnology provides new molecular contrasts agents and materials to enable earlier and more accurate initial diagnosis, as well as continual monitoring of patient while cancer treatment. This review concludes that nanotechnology as nanodrugs, nano carrier, nanoparticles in combination with radiological methods have a better future in cancer treatment. In this paper, several diagrammatic pathways presented the opted studies and proposed conclusion.

Keywords:

Cancer, Nanotechnology, Nanoparticles, Nanomaterials, Drug, Targeting,

Affiliation:

Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow, Uttar Pradesh, Department of Applied Physics, Aalto University, Espoo, Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow, Uttar Pradesh, Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow, Uttar Pradesh, Department of Health Informatics, College of Public Health and Health Informatics, Qassim University, Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow, Uttar Pradesh, Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow, Uttar Pradesh, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow, Uttar Pradesh



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