Submit Manuscript  

Article Details


From Molecular Mechanism to the Etiology of Sjogren Syndrome

[ Vol. 24 , Issue. 35 ]

Author(s):

Wei Wei, Syed Sayeed Ahmad, Shuang Chi, Yu Xie, Mohammad Amjad Kamal and Jiang Li*   Pages 4177 - 4185 ( 9 )

Abstract:


Sjogren's Syndrome (SS) is a chronic, female overwhelming fundamental issue of an immune system rheumatic sickness that influences the whole body. It is described by lymphocytic invasion of the exocrine viz. salivary and lacrimal glands and by surprising B-cell hyperactivity. Keratoconjunctivitis sicca (dry eye) and Stomatitis sicca (oral dryness) are the primary visual appearances of SS. The primary SS is recognized from secondary SS which happens as a piece of other immune system maladies. The secondary SS exists together particularly with fundamental lupus erythematosus (15- 36%), rheumatoid joint inflammation (20- 32%) and also restricted and progressive systemic sclerosis (11- 24%), less as often as possible with different sclerosis and immune system hepatitis and thyreoiditis. We assess changes in salivary epidermal growth factor (EGF) intensity and estimate the relationship between salivary EGF levels and the seriousness of intraoral symptoms in SS individuals. The outcomes demonstrated that the salivary EGF levels diminished with the movement of SS, and this crumbling in salivation quality and additionally, hyposalivation could imagine a vital constituent in the pathogenesis of refractory intraoral indication in SS suffering patients. A strong relationship between particular alleles of the MHC and SS improvement has been recommended. The primary hereditary examination on SS revealed a relationship amongst SS and HLA-DR3 in SS population. Subsequent reports featured the relationship amongst SS and the HLA-D locus, with a diverse distribution between primary SS and secondary SS. The motivation behind this manuscript is to give a concise survey on the molecular mechanism, effects of infectious agents and genetic factors in the etiology of Sjogren’s Syndrome. Such effects are discussed independently.

Keywords:

Sjogren's syndrome, immune system, keratoconjunctivitis sicca, stomatitis sicca, dryness, lupus erythematosus.

Affiliation:

Department of Prosthodontics, Dental Hospital, Jilin University, Changchun, Jilin 130021, Department of Bioengineering, Faculty of Engineering, Integral University, Lucknow, Department of Prosthodontics, Dental Hospital, Jilin University, Changchun, Jilin 130021, Department of Prosthodontics, Dental Hospital, Jilin University, Changchun, Jilin 130021, King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Department of Prosthodontics, Dental Hospital, Jilin University, Changchun, Jilin 130021



Read Full-Text article