Siva K. Korada, Nagendra S. Yarla, Vijayendra Mishra, Mohamed A. Daim, Bechan Sharma, Ashraf GM, Reggi R., Palmery M, Ilaria Peluso and Mohammad A. Kamal* Pages 4150 - 4153 ( 4 )
Strain, dose, duration, validated clinical trial studies and scientific substantiation of health claims are needed in order to define a successful probiotic. In particular, the potency of probiotic differs from strain to strain. In this view, we aimed to know whether the single strain or multi-strain construct is more beneficial. We found that the studies were still under debate and mechanisms remain sometimes unclear. No conclusion can be made based on the strain experimentation. Safety data and significant statistical results for efficacy via well-controlled clinical trials are needed.
Probiotics, health benefits, single strain, safety recommendation, multiple probiotics, gut microbiota.
National Institute of Food Technology Entrepreneurship and Management (NIFTEM), Sonepat, Haryana, Department of Animal Biology, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500 046, Telagana, National Institute of Food Technology Entrepreneurship and Management (NIFTEM), Sonepat, Haryana, Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Department of Biochemistry, University of Allahabad, Allahabad, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Department of Physiology and Pharmacology , Department of Physiology and Pharmacology , Research Center for Food and Nutrition, Council for Agricultural Research and Economics, (CREA-AN), Rome, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589