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Protective Mechanisms of Butyrate on Inflammatory Bowel Disease

[ Vol. 24 , Issue. 35 ]

Author(s):

Joao Paulo Bastos Silva, Kely Campos Navegantes-Lima, Ana Ligia Brito de Oliveira, Davila Valentina Silva Rodrigues, Silvia Leticia de Franca Gaspar, Valter Vinicius Silva Monteiro, Davi Pereira Moura and Marta Chagas Monteiro*   Pages 4154 - 4166 ( 13 )

Abstract:


Inflammatory bowel disease (IBD) is a multifactorial chronic disease, commonly associated with alteration in the composition and function of gut microbiota. This process can lead to a decreased production of short chain fatty acids (SCFAs) by the gut microbiota, mainly butyrate, which is an important immunomodulatory molecule in the intestine. Butyrogenic bacteria normally produces butyrate through carbohydrate fermentation or amino acids degradation pathways. This molecule plays an important protective role in intestinal homeostasis acting in both adaptive immunity and innate immunity. This review summarizes the current knowledge about the role of butyrate on the development of IBD and the protective mechanisms of this metabolite on the intestinal mucosa and the whole body, as reported by in vitro and in vivo studies. Thus, butyrate can regulate the activation of regulatory T cells, increasing the acetylation of histones and decreasing the activation of NF-κB. In addition, it can also stimulate the mucus production from epithelial cells and the rearrangement of tight junction proteins.

Keywords:

Butyrate, short chain fatty acids, SCFA, Inflammatory bowel disease, IBD, inflammation, Ulcerative Colitis, Crohn’s disease.

Affiliation:

Neuroscience and Cellular Biology Post Graduation Program, Institute of Biological Sciences, Federal University of Para, Avenue Augusto Correa SN, Guama, Para 66075-110, Neuroscience and Cellular Biology Post Graduation Program, Institute of Biological Sciences, Federal University of Para, Avenue Augusto Correa SN, Guama, Para 66075-110, Pharmaceutical Science Post-Graduation Program, Faculty of Pharmacy, Federal University of Para, Avenue Augusto Correa SN, Guama, Para 66075-110, School of Pharmacy, Health Science Institute, Federal University of Pará/UFPA, Avenue Augusto Correa SN, Guama, Para 66075-110, School of Pharmacy, Health Science Institute, Federal University of Pará/UFPA, Avenue Augusto Correa SN, Guama, Para 66075-110, Laboratory of Inflammation and Pain, Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Sao Paulo 14049-900, School of Pharmacy, Health Science Institute, Federal University of Pará/UFPA, Avenue Augusto Correa SN, Guama, Para 66075-110, Neuroscience and Cellular Biology Post Graduation Program, Institute of Biological Sciences, Federal University of Para, Avenue Augusto Correa SN, Guama, Para 66075-110



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