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New Approaches for Weight Loss: Experiments Using Animal Models

[ Vol. 24 , Issue. 18 ]

Author(s):

Magnus K. Olsen*, Helene Johannessen, Reshma Ramracheya, Chun-Mei Zhao and Duan Chen   Pages 1926 - 1935 ( 10 )

Abstract:


The number of people who are overweight and obese are continuously increasing both in the adult and adolescent populations. Coinciding with this is the increased prevalence of health problems such as type 2 diabetes (T2D). Bariatric surgery is the only proven long-term treatment of obesity and may induce remission of T2D, although the underlying mechanisms are unknown. The translational studies presented here might provide insight on the mechanism of steady-state energy balance of the obese phenotype using a special time-restricted feeding regimen for weight loss during the steady-state energy balance; mechanism by vagal blocking therapy (vBLocĀ® therapy) as a new treatment for obesity; and possible mechanism behind the remission of T2D following gastric bypass surgery.

Keywords:

Energy balance, PYY, time-restricted feeding, vagus nerve, obese, bariatric surgery.

Affiliation:

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim



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