Submit Manuscript  

Article Details

The Several Activities of 4 - Methyl Pyrazole in Animals and Humans

[ Vol. 24 , Issue. 18 ]


Gaetano Iaquinto*   Pages 1957 - 1960 ( 4 )


4-MP is a potent competitive inhibitor of ADH activity with an affinity about a 1000 times more than toxic alcohols. 4-MP was shown to reduce the formation of toxic metabolites in lethal methanol and ethylene glycol poisoning in animal models and in methanol poisoning in humans. 4-MP has long-lasting gastroprotective effect against ethanol and other chemically induced acute gastric mucosa lesions in rats. We showed, for the first time, that 4-MP also provides significant protection of the human stomach against alcohol induced acute mucosal injury.


4 methyl pyrazole, alchol gastric, mucosal injury, gastroprotection, ADH, ethanol, alcohol.


Gastroenterology and Digestive Endoscopy Service, S. Rita Clinic, via Appia, 83042, Atripalda

Read Full-Text article