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The Several Activities of 4 - Methyl Pyrazole in Animals and Humans

[ Vol. 24 , Issue. 18 ]

Author(s):

Gaetano Iaquinto*   Pages 1957 - 1960 ( 4 )

Abstract:


4-MP is a potent competitive inhibitor of ADH activity with an affinity about a 1000 times more than toxic alcohols. 4-MP was shown to reduce the formation of toxic metabolites in lethal methanol and ethylene glycol poisoning in animal models and in methanol poisoning in humans. 4-MP has long-lasting gastroprotective effect against ethanol and other chemically induced acute gastric mucosa lesions in rats. We showed, for the first time, that 4-MP also provides significant protection of the human stomach against alcohol induced acute mucosal injury.

Keywords:

4 methyl pyrazole, alchol gastric, mucosal injury, gastroprotection, ADH, ethanol, alcohol.

Affiliation:

Head of Gastroenterology and Digestive Endoscopy, St. Rita Hospital, Atripalda (AV)



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