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Anti-Cancer and Radio-Sensitizing Effects of Curcumin in Nasopharyngeal Carcinoma

[ Vol. 24 , Issue. 19 ]

Author(s):

Amir Abbas Momtazi-Borojeni, Faezeh Ghasemi, Amirreza Hesari, Muhammed Majeed, Michele Caraglia and Amirhossein Sahebkar*   Pages 2121 - 2128 ( 8 )

Abstract:


Nasopharyngeal Cancer (NPC) is a rare type of head and neck cancer that is mainly treated by radiotherapy, but sometimes it is radioresistant. Curcumin is a polyphenolic natural product with established anticancer effects in various human cancers. Recent studies have shown that curcumin has therapeutic and radiosensitizing effects on NPC cells. In fact, it has been found that curcumin can sensitize NPC cells to radiation through different mechanisms, including modulation of ROS generation, Jab1/CSN5 and non-coding RNAs. As curcumin is safe and lacks systemic toxic effects in humans, it may be considered as a potential candidate to enhance the therapeutic effects of radiation and potentiate the efficacy of chemotherapy in the context of combination regimens.

Keywords:

Apoptosis, curcumin, nasopharyngeal cancer, non-coding RNA, tropical, chemotherapy.

Affiliation:

Nanotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Department of Medical Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Sabinsa Corporation, East Windsor, NJ, Department of Biochemistry, Biophysics and General Pathology, University of Campania "L. Vanvitelli", Via L. De Crecchio 7, Naples, Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad 9177948564



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