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Nanocrystals Technology for Pharmaceutical Science

[ Vol. 24 , Issue. 21 ]

Author(s):

Zhongyao Cheng, Yumei Lian, Zul Kamal, Xin Ma, Jianjun Chen, Xinbo Zhou*, Jing Su* and Mingfeng Qiu*   Pages 2497 - 2507 ( 11 )

Abstract:


Background: Nanocrystals technology is a promising method for improving the dissolution rate and enhancing the bioavailability of poorly soluble drugs. In recent years, it has been developing rapidly and applied to drug research and engineering. Nanocrystal drugs can be formulated into various dosage forms.

Objective: This review mainly focused on the nanocrystals technology and its application in pharmaceutical science. Firstly, different preparation methods of nanocrystal technology and the characterization of nanocrystal drugs are briefly described. Secondly, the application of nanocrystals technology in pharmaceutical science is mainly discussed followed by the introduction of sustained release formulations. Then, the scaling up process, marketed nanocrystal drug products and regulatory aspects about nanodrugs are summarized. Finally, the specific challenges and opportunities of nanocrystals technology for pharmaceutical science are summarized and discussed.

Conclusion: This review will provide a comprehensive guide for scientists and engineers in the field of pharmaceutical science and biochemical engineering.

Keywords:

Nanocrystals technology, poorly soluble drugs, delivery, scale-up, market, regulatory.

Affiliation:

School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, 510515, Laboratory of Computer- Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240



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