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Polyunsaturated Fatty Acids and Cardiovascular Disease

[ Vol. 15 , Issue. 36 ]


Ivan Calzolari, Stefano Fumagalli, Niccolo Marchionni and Mauro Di Bari   Pages 4094 - 4102 ( 9 )


Several observational and experimental studies show the beneficial effects of ω-3 poly-unsaturated fatty acids (PUFA) in cardiovascular disease. The results from such studies justify supplementation of ω-3 PUFA in primary and secondary prevention of several clinical conditions, including coronary heart disease, sudden cardiac death and heart failure. Supplementation of ω-3 PUFA is also indicated as monotherapy in the treatment of hypertriglyceridemia. Analysis of their biological actions suggests a variety of anti-arrhythmic, anti-thrombotic, anti-atherosclerotic and antiinflammatory mechanisms underlying their clinical benefits.


Polyunsaturated fatty acids,cardiovascular disease,sudden death,coronary heart disease,heart failure


, , , Department of Critical Care Medicine and Surgery, Unit of Gerontology and Geriatrics, University of Florence, via delle Oblate, 4, 50141 Florence, Italy.

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