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Neuroprotection in Hypoxic-Ischemic Brain Injury Targeting Glial Cells

[ Vol. 23 , Issue. 26 ]

Author(s):

Sofia Mucci, Maria Ines Herrera, George E. Barreto, Rodolfo Kolliker-Frers and Francisco Capani   Pages 3899 - 3906 ( 8 )

Abstract:


Brain injury constitutes a disabling health condition of several etiologies. One of the major causes of brain injury is hypoxia-ischemia. Until recently, pharmacological treatments were solely focused on neurons. In the last decades, glial cells started to be considered as alternative targets for neuroprotection. Novel treatments for hypoxia-ischemia intend to modulate reactive forms of glial cells, and/or potentiate their recovery response. In this review, we summarize these neuroprotective strategies in hypoxia-ischemia and discuss their mechanisms of action.

Keywords:

brain injury, hypoxia-ischemia, pharmacological treatments, glial cells, neuroprotection

Affiliation:

Laboratorio de Citoarquitectura y Plasticidad Neuronal, Facultad de Medicina, Instituto de Investigaciones Cardiologicas Prof. Dr. Alberto C. Taquini (ININCA), UBA-CONICET, CABA, Buenos Aires, Laboratorio de Citoarquitectura y Plasticidad Neuronal, Facultad de Medicina, Instituto de Investigaciones Cardiologicas Prof. Dr. Alberto C. Taquini (ININCA), UBA-CONICET, CABA, Buenos Aires, Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana Bogota, D.C., Colombia, Laboratorio de Citoarquitectura y Plasticidad Neuronal, Facultad de Medicina, Instituto de Investigaciones Cardiologicas Prof. Dr. Alberto C. Taquini (ININCA), UBA-CONICET, CABA, Buenos Aires, Laboratorio de Citoarquitectura y Plasticidad Neuronal, Facultad de Medicina, Instituto de Investigaciones Cardiologicas Prof. Dr. Alberto C. Taquini (ININCA), UBA-CONICET, CABA, Buenos Aires



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