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Hybrid Materials and Nanocomposites as Multifunctional Biomaterials

[ Vol. 23 , Issue. 26 ]

Author(s):

Heveline D. M. Follmann, Alliny F. Naves, Rafael A. Araujo, Viktor Dubovoy, Xiaoxi Huang, Tewodros Asefa, Rafael Silva and Osvaldo N. Oliveira *   Pages 3794 - 3813 ( 20 )

Abstract:


This review article provides an overview of hybrid and nanocomposite materials used as biomaterials in nanomedicine, focusing on applications in controlled drug delivery, tissue engineering, biosensors and theranostic systems. Special emphasis is placed on the importance of tuning the properties of nanocomposites, which can be achieved by choosing appropriate synthetic methods and seeking synergy among different types of materials, particularly exploiting their nanoscale nature. The challenges in fabrication for the nanocomposites are highlighted by classifying them as those comprising solely inorganic phases (inorganic/inorganic hybrids), organic phases (organic/organic hybrids) and both types of phases (organic/inorganic hybrids). A variety of examples are given for applications from the recent literature, from which one may infer that significant developments for effective use of hybrid materials require a delicate balance among structure, biocompatibility, and stability.

Keywords:

Hybrid materials, nanocomposites, multifunctional biomaterials, theranostic systems, drug delivery systems, inorganic hybrids.

Affiliation:

Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, Institute of Chemistry, University of Sao Paulo (USP), CP 26077, CEP 05513-970, Sao Paulo, Department of Chemistry, State University of Maringa (UEM) - Av. Colombo 5790 - CEP 87020-90, Maringa, Parana, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, Department of Chemistry, State University of Maringa (UEM) - Av. Colombo 5790 - CEP 87020-90, Maringa, Parana, Sao Carlos Institute of Physics, University of Sao Paulo (USP) - PO Box 369, CEP 13566-590, Sao Carlos, Sao Paulo



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