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Polyamine Transport and Synthesis in Trichomonas vaginalis: Potential Therapeutic Targets

[ Vol. 23 , Issue. 23 ]

Author(s):

Maria Elizbeth Alvarez-Sanchez, Jose Luis Villalpando, Laura Itzel Quintas-Granados and Rossana Arroyo*   Pages 3359 - 3366 ( 8 )

Abstract:


Polyamines are essential for many biological processes in all organisms. Here we show a current landscape of studies and strategies implemented for the study of polyamine metabolism, as well as molecular aspects that implicate the role of key enzymes, transport proteins, inhibitors, and the study of novel molecules as potential therapeutic targets. This review focused on the synthesis, interconversion and function of these molecules in Trichomonas vaginalis, a common sexually transmitted parasite of humans.

Keywords:

Hypusination machinery, ornithine decarboxylase (ODC), polyamines, polyamine oxidase (PAO), putrescine, spermine, spermidine, Trichomonas vaginalis.

Affiliation:

Posgrado en Ciencias Genomicas, Universidad Autonoma de la Ciudad de Mexico (UACM), San Lorenzo # 290, Col. Del Valle, CP 03100. Mexico City, Posgrado en Ciencias Genomicas, Universidad Autonoma de la Ciudad de Mexico (UACM), San Lorenzo # 290, Col. Del Valle, CP 03100. Mexico City, Posgrado en Ciencias Genomicas, Universidad Autonoma de la Ciudad de Mexico (UACM), San Lorenzo # 290, Col. Del Valle, CP 03100. Mexico City, R.A. Av. IPN # 2508, Col. San Pedro Zacatenco, Delg. Gustavo A. Madero, CP 07360, Mexico, D.F



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