Elham Pishavar and Javad Behravan* Pages 3309 - 3314 ( 6 )
Diabetes mellitus (DM) is a metabolic disorder which is characterized by inappropriate hyperglycemia. It is becoming an epidemic disease in developing countries. Diabetic patients are frequently afflicted with a vascular dysfunction and wound healing defect. In spite of intense investigations, over the past 2-3 decades, optimal treatment options and related mechanisms are still unclear. MicroRNAs (miRNAs) are small noncoding RNAs considered as regulators of a vast number of biological processes including endothelial cell function controlling molecular signaling pathways in diabetic pathogenesis. Down regulation of microRNA-126 (miR-126) which may regulate angiogenesis and vascular integrity plays a significant role in the pathogenesis and complications of DM. This paper discusses the potential application of miR-126 as a novel therapeutic agent capable of reducing diabetic vascular complications in different types of DM based on the up-to-date reports.
Angiogenesis, diabetes mellitus, miR-126, vascular complications, microRNAs, hyperglycemia.
Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad