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Congenital Hypothyroidism: Facts, Facets & Therapy

[ Vol. 23 , Issue. 16 ]

Author(s):

Yedukondalu Kollati, Ranga Rao Ambati, Prakash Narayana Reddy, N. Satya Sampath Kumar, Rajesh K. Patel* and Vijaya R. Dirisala*   Pages 2308 - 2313 ( 6 )

Abstract:


Background: Thyroid hormone (T3) is essential for normal development of children enabling brain development and somatic growth. However, certain individuals are genetically predisposed with insufficient or no thyroid hormones. Such a condition is termed congenital hypothyroidism (CH).

Objective: In the present review, a brief back ground about congenital hypothyroidism, factors associated with CH leading to thyroid dysgenesis and thyroid dyshormonogenesis is elaborated. Additionally, the guidelines for available treatment options, management and follow-up required for patients diagnosed with CH are discussed. Treatment options in terms of treatment initiation and dosage of hormone replacement are discussed.

Conclusion: Though CH is considered as the most common neonatal metabolic disorder, it is also easily treatable compared to other metabolic or hereditary diseases. The outcome of CH treatment depends on the compliance of parents early in life and by patients themselves during later part of life.

Keywords:

Congenital hypothyroidism, hormone therapy, levothyroxine, thyroid gland, transcription factors, Thyroid hormone (T3).

Affiliation:

Department of Biotechnology, Vignan's Foundation for Science, Technology and Research University (VFSTRU), Guntur 522213, Andhra Pradesh, Food Science and Technology Programme, Beijing Normal University-Hong Kong Baptist University United International College, 28, Jinfeng Road, Tangjiawan, Zhuhai-519085, Guangdong, Department of Biotechnology, Vignan's Foundation for Science, Technology and Research University (VFSTRU), Guntur 522213, Andhra Pradesh, Department of Biotechnology, Vignan's Foundation for Science, Technology and Research University (VFSTRU), Guntur 522213, Andhra Pradesh, Sandor Animal Biogenics Private Limited, Sandor Life Sciences, Telangana-500043, Department of Biotechnology, Vignan’s Foundation for Science, Technology and Research University (VFSTRU), Guntur-5222, Andhra Pradesh



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