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Research Article

Enhanced Wound Healing with Rhodiola rosea Phytosomal Gel: Extraction, Formulation, and In vivo Evaluation

Author(s):

Anandarajagopal Kalusalingam*, Abdullah Khan, Mahibub Mahamadsa Kanakal, Syed Atif Abbas, Chiau Ming Long, Tazneem B., Ching Siang Tan, Abubakar Salam Bawazir, Abdul Razak T. K. and Roshan S   Pages 1 - 15 ( 15 )

Abstract:


Background: This study explores the formulation and effectiveness of a Rhodiola rosea phytosomal gel for enhancing wound healing.

Object: The ethanolic extract of Rhodiola rosea roots, rich in bioactive compounds like alkaloids and flavonoids, was optimized into a phytosomal complex to improve absorption and dermal retention.

Method: Characterization through GC-MS revealed compounds, such as 2-Heptadecenal and Bicyclo[ 4.1.0]Heptane and 7-Pentyl. FTIR confirmed the successful encapsulation within the phospholipid bilayer, while SEM showed smooth, spherical particles.

Result: The Box-Behnken design optimized formulation parameters, achieving high yield (92.64%), small particle size (355 nm), and high entrapment efficiency (93.98%). In vitro release studies displayed a consistent release profile, aligning with Zero-order and Hixson-Crowell models. In vivo evaluation on Wistar rats showed that the phytosomal gel significantly enhanced wound healing, achieving 98.16% wound reduction by day 14, compared to 95.17% for R. rosea extract and 97.13% for standard treatment. Histopathological analysis demonstrated complete tissue regeneration and well-organized collagen fibers in the phytosomal gel group.

Conclusion: This research highlights the potential of Rhodiola rosea phytosomal gel as an effective wound healing therapy, with future studies suggested for extended stability tests and human skin permeation studies.

Keywords:

Rhodiola rosea, phytosomal gel, wound healing, extraction, Box-Behnken design, in vivo evaluation.

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