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The Role of Biologically Active Ingredients from Chinese Herbal Medicines in the Regulation of Autophagy in Treating Cardiovascular Diseases and Other Chronic Diseases

[ Vol. 23 , Issue. 7 ]

Author(s):

Jie Li, Yonghong Gao, Xiaomeng Ren, Yanda Li, Lijun Wu, Xinyu Yang, Jie Wang, Hongcai Shang, Xingjiang Xiong* and Yanwei Xing*   Pages 1060 - 1069 ( 10 )

Abstract:


Autophagy, a highly conserved starvation response mechanism with both defensive and protective effects in eukaryotic cells, is a lysosome-mediated degradation process for non-essential or damaged cellular constituents. It plays an important role in the cell survival, differentiation and development to maintain homeostasis. Autophagy is involved in cardiovascular diseases, cerebrovascular diseases, and neurodegenerative diseases, as well as tumours. Thus, modulating autophagy may provide potential therapeutic strategies. Recently, many active components of Chinese herbal medicines (CHM) have been found to modulate autophagy in myocardial cells, cerebral vascular cells, endothelial cells and tumour cells. This paper reviews the advances in studies on the active components of CHM that modulating autophagy in treating cardiovascular diseases and other chronic diseases over the past five years.

Keywords:

Autophagy, biologically active ingredients, Chinese herbal medicines, cardiovascular diseases, cerebrovascular diseases, tumours, neurodegenerative disease.

Affiliation:

Department of Cardiology, Guang`anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, The Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, The Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, Department of Cardiology, Guang`anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, The Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, The Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, Department of Cardiology, Guang`anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, The Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, Department of Cardiology, Guang`anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, Department of cardiology, Guang`anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing



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