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Calixarene: A Versatile Material for Drug Design and Applications

[ Vol. 23 , Issue. 16 ]

Author(s):

Muhammad A. Hussain*, Muhammad U. Ashraf, Gulzar Muhammad, Muhammad N. Tahir and Syed N. A. Bukhari   Pages 2377 - 2388 ( 12 )

Abstract:


The therapy of various diseases by the drugs entrapped in calixarene derivatives is gaining attraction of researchers nowadays. Calixarenes are macrocyclic nano-baskets which belong to cavitands class of host-guest chemistry. They are the marvelous hosts with distinct hydrophobic three dimensional cavities to entrap and encapsulate biologically active guest drugs. Calixarene and its derivatives develop inclusion complexes with various types of drugs and vitamins for their sustained/targeted release. Calixarene and its derivatives are used as carriers for anti-cancer, anti-convulsant, anti-hypertensive, anthelmentic, anti-inflammatory, antimicrobial and antipsychotic drugs. They are the important biocompatible receptors to improve solubility, chemical reactivity and decrease cytotoxicity of poorly soluble drugs in supramolecular chemistry. This review focuses on the calixarene and its derivatives as the state-of-the-art in host-guest interactions for important drugs. We have also critically evaluated calixarenes for the development of prodrugs.

Keywords:

Calixarene, supramolecular, medicinal uses, drug release, prodrugs, drug design.

Affiliation:

Department of Chemistry, University of Sargodha, Sargodha 40100, Faculty of Pharmacy, Department of Pharmaceutics, University of Sargodha, Sargodha 40100,, Department of Chemistry, University of Sargodha, Sargodha 40100, Institute of Inorganic and Analytical Chemistry, Johannes Guttenberg University, Duesbergweg 10-14, 55128 Mainz, Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, 50300



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