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Molecular Mechanisms of Drug Photodegradation and Photosensitization

[ Vol. 22 , Issue. 7 ]

Author(s):

Mohd Rehan Zaheer, Anamika Gupta, Jawaid Iqbal, Qamar Zia, Akil Ahmad, Roohi, Mohammad Owais, Ali Hashlamon, Siti Hamidah Mohd Setapar, Ghulam Md Ashraf and Gjumrakch Aliev   Pages 768 - 782 ( 15 )

Abstract:


Drug-induced photosensitivity of the skin is drawing increasing attention. In past few decades, photosensitivity has been reported with an array of drugs, and is now recognized as a noteworthy medical problem by clinicians, regulatory authorities and pharmaceutical industry. The photosensitivity is of two types i.e., phototoxicity and photoallergy. Phototoxic disorders have a high incidence, whereas photoallergic reactions are much less frequent in human population. Several hundred substances, chemicals, or drugs may invoke phototoxic and photoallergic reactions. In order to avoid photosensitive reactions, it is essential to understand the mechanism behind the photosensitizing properties of such substances before these drugs are introduced in clinical settings. Photosensitization is inter-related to photochemical reaction, through the knowledge of which the photosensitivity of a drug can be anticipated. This review highlights the current research status on photosensitizing drugs and its correlation to phototoxicity. Different mechanisms of photodegradation of photolabile drugs have also been discussed.

Keywords:

Drug, photoallergy, photodegradation, photosensitization, phototoxicity.

Affiliation:

Department of Chemistry Aligarh Muslim University Aligarh-202001, UP, India., Department of Biotechnology, Gagan College of Management and Technology, Aligarh 202001, UP India., “GALLY” International Biomedical Research Consulting LLC, San Antonio, TX 78229, USA.



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