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Review Article

Antitumor Effects of Curcumin on Cervical Cancer with the Focus on Molecular Mechanisms: An Exegesis

[ Vol. 29 , Issue. 42 ]

Author(s):

Ali Govahi, Neda Zahmatkesh, Omid Pourbagherian, Neda Maleki Khas, Tala Salamzadeh, Hasti Moshtagh Mehr, Esmaeil Babaei* and Mahsa Hajivalili*   Pages 3385 - 3399 ( 15 )

Abstract:


Cervical cancer is one of the most prevalent malignancies among females and is correlated with a significant fatality rate. Chemotherapy is the most common treatment for cervical cancer; however, it has a low success rate due to significant side effects and the incidence of chemo-resistance. Curcumin, a polyphenolic natural compound derived from turmeric, acts as an antioxidant by diffusing across cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it performs its effects. As a result, it's been promoted as a chemo-preventive, anti-metastatic, and anti-angiogenic agent. As a consequence, the main goal of the present review was to gather research information that looked at the link between curcumin and its derivatives against cervical cancer.

Keywords:

Curcumin, cervical cancer, herbal remedy, curcumin limitation, curcumin nanoparticles, <i>Curcuma longa</i>.

Affiliation:



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