Haowen Fang, Yanting Ding, Yi Lu, Bing Niu*, Han Lu* and Qin Chen* Pages 1266 - 1273 ( 8 )
Background: Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies have shown that silibinin has the potential to inhibit neuraminidase activity.
Objective: This study aims to explore the interaction between silibinin and neuraminidase and the effect of silibinin on the structure and activity of neuraminidase.
Methods: In this study, two-dimensional fluorescence spectrum, three-dimensional fluorescence spectrometry, Uv-vis spectroscopy, and circular dichroism analysis were used.
Results: Silibinin alters the secondary structure of neuraminidase and inhibits the activity of neuraminidase.
Conclusion: Silibinin can interact with neuraminidase and inhibit its activity.
Neuraminidase, neuraminidase inhibitor, drugs, avian influenza virus, silibinin, Uv-vis spectroscopy, Peramivir.