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Research Article

Study on the Interaction between Silibinin and Neuraminidase

[ Vol. 29 , Issue. 16 ]


Haowen Fang, Yanting Ding, Yi Lu, Bing Niu*, Han Lu* and Qin Chen*   Pages 1266 - 1273 ( 8 )


Background: Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies have shown that silibinin has the potential to inhibit neuraminidase activity.

Objective: This study aims to explore the interaction between silibinin and neuraminidase and the effect of silibinin on the structure and activity of neuraminidase.

Methods: In this study, two-dimensional fluorescence spectrum, three-dimensional fluorescence spectrometry, Uv-vis spectroscopy, and circular dichroism analysis were used.

Results: Silibinin alters the secondary structure of neuraminidase and inhibits the activity of neuraminidase.

Conclusion: Silibinin can interact with neuraminidase and inhibit its activity.


Neuraminidase, neuraminidase inhibitor, drugs, avian influenza virus, silibinin, Uv-vis spectroscopy, Peramivir.


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