Francis Victor, Kanwal Rehman, Muhammad Sajid Hamid Akash*, Sumbal Rasheed, Muhammad Imran and Mohammed Ali Assiri Pages 893 - 903 ( 11 )
Being an important dietary component, omega-3 (ω-3) fatty acids are essential polyunsaturated fatty acids, which play a crucial role in the normal growth and development of an individual. ω-3 fatty acids have been reported to possess therapeutic activities against several diseases, including cardiovascular, neurological, cancer, etc. Due to the unsaturation, ω-3 fatty acids are highly reactive and prone to oxidation, which is the biggest hurdle in their administration, as oxidation produces a foul smell and reduces their therapeutic efficacy. Although numerous supplementation strategies have been developed to enhance the bioavailability, targeted drug delivery, and therapeutic potential, the rate of compliance is low due to difficulty in swallowing and unpleasant aftertaste. To cope with these problems, several novel drug delivery approaches have been developed, which may be used as an alternative to enhance the effectiveness of ω-3 fatty acids when administered alone or in combination therapy. This review focuses on how novel drug delivery approaches can be used to overcome the ω-3 fatty acids stability issues and how to maximize its therapeutic activity.
ω-3 fatty acid, PUFAs, nano-formulations, bioavailability, stability, micro-formulations, target drug delivery.