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Telomere Maintenance Mechanisms in Cancer: Clinical Implications

[ Vol. 20 , Issue. 41 ]

Author(s):

Roger R. Reddel   Pages 6361 - 6374 ( 14 )

Abstract:


The presence of immortal cell populations with an up-regulated telomere maintenance mechanism (TMM) is an almost universal characteristic of cancers, whereas normal somatic cells are unable to prevent proliferation-associated telomere shortening and have a limited proliferative potential. TMMs and related aspects of telomere structure and function therefore appear to be ideal targets for the development of anticancer therapeutics. Such treatments would be targeted to a specific cancer-related molecular abnormality, and also be broad-spectrum in that they would be expected to be potentially applicable to most cancers. However, the telomere biology of normal and malignant human cells is a relatively young research field with large numbers of unanswered questions, so the optimal design of TMM-targeted therapeutic approaches remains unclear. This review outlines the opportunities and challenges presented by telomeres and TMMs for clinical management of cancer.

Keywords:

Alternative lengthening of telomeres, cancer, diagnosis, prognosis, telomerase, telomeres, therapy.

Affiliation:

Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, New South Wales 2145, Australia.



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