Yuan Li, Sheng Zhao, Leanne Van der Merwe, Wentong Dai and Cai Lin* Pages 187 - 197 ( 11 )
Background: Curcumin possesses multiple bioactivities that have beneficial effects on diabetic foot ulcers. Herein, we aimed to conduct a preclinical systematic review of 9 studies, including a total of 262 animals, to assess the possible mechanisms of curcumin for wound healing in diabetic animals.
Methods: Five databases were searched from inception to May 12, 2020; Rev-Man 5.3 software was applied for data analyses. Cochrane Collaboration’s tool 10-item checklist was used to evaluate the methodological quality, and data revealed scores of risk of bias ranging from 2 to 5.
Results: Meta-analysis indicated that curcumin had significant effects on wound healing rate and blood vessel density when compared with control (P < 0.05). The wound regeneration properties of curcumin for diabetic wounds are thought to mainly work through the possible mechanisms of antioxidation, enhanced cell proliferation, increased collagen formation, and angiogenesis. However, the anti-inflammatory effect on wounds in diabetic animals remain controversial.
Conclusion: The findings indicate that more randomized controlled trials should be pursued to obtain more reliable results regarding inflammatory response. Overall, curcumin might be a probable candidate for diabetic foot ulcers and may contribute to future clinical trials.
Angiogenesis, curcumin, diabetic foot ulcers, meta-analysis, preclinical evidence, wound healing, systematic review.
Department of Burn, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Department of Burn, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, School of International Studies, Wenzhou Medical University, Wenzhou, Zhejiang 325000, Department of Burn, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Department of Burn, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000