Margarita E. Neganova, Sergey G. Klochkov, Yulia R. Aleksandrova and Gjumrakch Aliev* Pages 8139 - 8162 ( 24 )
Hydroxamic acids are a promising class of chemical compounds with proven antitumor potential, primarily due to their ability to inhibit the activity of histone deacetylase enzymes. The analysis of modern experimental data shows a wide range of biological activities of hydroxamic acids, which make them equally worthy candidates for the fight against neuropathologies. A characteristic feature of hydroxamic acids is their ability to act simultaneously on several promising molecular targets for the correction of both neuropathologies and oncological diseases, thereby exhibiting multifunctionality. This review discusses the effect of hydroxamic acids on key parts of cancer and neurodegenerative disorders' pathogenesis. Pathological changes in the processes associated with oxidative stress, the functioning of mitochondria, and the activity of metal enzymes of the class of histone deacetylases, as the main links in the epigenetic regulation of pathological conditions, are such molecular targets.
Hydroxamic acids, cancer, neurodegenerative diseases, oxidative stress, mitochondria, histone deacetylase.
Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka