Yujie Shen, Yexiang Lin, Kai Liu, Jinlan Chen, Juanjuan Zhong, Yisong Gao and Chengfu Yuan* Pages 1407 - 1417 ( 11 )
Background: A number of studies have proposed that lncRNA XIST plays a role in the development and chemosensitivity of NSCLC. Besides, XIST may become a potential therapeutic target for NSCLC patients. The aim of this review is to reveal the biological functions and exact mechanisms of XIST in NSCLC.
Methods: In this review, relevant researches involving the relationship between XIST and NSCLC are collected through systematic retrieval of PubMed.
Results: XIST is an oncogene in NSCLC and is abnormally upregulated in NSCLC tissues. Considerable evidence has shown that XIST plays a critical role in the proliferation, invasion, migration, apoptosis and chemosensitivity of NSCLC cells. XIST mainly functions as a ceRNA in the NSCLC process, while XIST also functions at transcriptional levels.
Conclusion: LncRNA XIST has the potential to become a novel biomolecular marker of NSCLC and a therapeutic target for NSCLC.
XIST, NSCLC, therapeutic target, biomolecular marker, noncoding, RNA.
College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002