Nimra Javaid, Muhammad A. Shah*, Azhar Rasul, Zunera Chauhdary, Uzma Saleem, Haroon Khan, Nazir Ahmed, Md. Sahab Uddin, Bijo Mathew, Tapan Behl and Renald Blundell Pages 3591 - 3601 ( 11 )
Neurodegeneration is a multifactorial process involved the different cytotoxic pathways that lead to neuronal cell death. Alzheimer’s disease (AD) is a persistent neurodegenerative disorder that normally has a steady onset and gradually worsens. Neuropathology, AD is characterized by the presence of neuroinflammation, mitochondrial dysfunction, increased oxidative stress, decreased antioxidant defense as well as increased acetylcholinesterase activity. Moreover, enhanced expression of amyloid precursor proteins leads to neural apoptosis, which has a vital role in the degeneration of neurons. The inability of commercial therapeutics to treat a single feature of AD pathology leads to the attraction towards organic drugs. Ellagic acid is a dimer of gallic acid; latest studies revealed that ellagic acid can initiate numerous cell signaling transmissions and decrease the progression of neurodegeneration. The neuroprotective effects of ellagic acid to protect the neurons against neurodegenerative events are due to its antioxidant effect, iron chelating, and mitochondrial protective effect. The main goal of this review is to critically analyze the molecular mechanism of action of ellagic acid against AD.
Ellagic acid, Alzheimer's disease, antioxidant activity, acetylcholinesterase, mitochondrial dysfunction, neurodegeneration, cell signaling.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Department of Pharmacy, Abdul Wali Khan University, Mardan, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Department of Pharmacy, Southeast University, Dhaka, Bangladesh; 6Pharmakon Neuroscience Research Network, Dhaka, Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi-682041, Chitkara College of Pharmacy, Chitkara University, Punjab, Department of Physiology and Biochemistry, University of Malta, Msida, MSD2080