Maria Bozko and Przemyslaw Bozko* Pages 4586 - 4587 ( 2 )
Cell-to-cell transmission of the unfolded protein response (UPR) is one of the most exciting observations recently made in cell biology. One of the most efficient tools to induce UPR response in cell culture is treatment with specific compounds leading to accumulation of misfolded proteins in endoplasmic reticulum. In this article we discussed opposite opinions regarding application of this approach and possible sources of experimental artefacts.
Endoplasmic reticulum, unfolded protein response, conditioned media, UPR, unfolded protein, cell-tocell transmission, response.
Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Department of Internal Medicine I, Universitätsklinikum Tübingen, Tübingen