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Review Article

Chalcones: Retrospective Synthetic Approaches and Mechanistic Aspects of a Privileged Scaffold

[ Vol. 26 , Issue. 24 ]


Emília P.T. Leitão*   Pages 2843 - 2858 ( 16 )


This review summarizes the synthetic methodologies used in the last 25 years for the synthesis of chalcones, which are a class of flavonoids having a 1,3-diphenyl-2-propene-1-one backbone. These compounds are considered a hot topic in the field of medicinal chemistry, due to their pharmacological activity and because they are important precursors for the synthesis of heterocyclic compounds with therapeutic applications such as: flavones, flavanones, isoxazolines, benzothiazepines, pyrimidines and pyrazolines derivatives.


Chalcones, scaffold, medicinal chemistry, pharmacological activity, flavones, flavanones, isoxazolines, benzothiazepines, pyrimidines, pyrazolines derivatives.


Hovione, FarmaCiencia SA, Estrada do Paço do Lumiar, Campus do Lumiar, Building S, 1649-038 Lisboa

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