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Fibroblast Growth Factor Receptor Inhibitors

[ Vol. 19 , Issue. 4 ]

Author(s):

Suneel Kumar B.V.S, Lakshmi Narasu, Rambabu Gundla, Raveendra Dayam and Sarma J.A.R.P   Pages 687 - 701 ( 15 )

Abstract:


Fibroblast growth factor receptors (FGFRs) play an important role in embryonic development, angiogenesis, wound healing, cell proliferation and differentiation. The fibroblast growth factor receptor (FGFR) isoforms have been under intense scrutiny for effective anticancer drug candidates. The fibroblast growth factor (FGF) and its receptor (FGFR) provide another pathway that seems critical to monitoring angiogenesis. Recent findings suggest that FGFR mediates signaling, regulates the PKM2 activity, and plays a crucial role in cancer metabolism. The current review also covers the recent findings on the role of FGFR1 in cancer metabolism. This paper reviews the progress, mechanism, and binding modes of recently known kinase inhibitors such as PD173074, SU series and other inhibitors still under clinical development. Some of the structural classes that will be highlighted in this review include Pyrido[2,3-d]pyrimidines, Indolin- 2-one, Pyrrolo[2,1-f][1,2,4]triazine, Pyrido[2,3-d]pyrimidin-7(8H)-one, and 1,6- Naphthyridin-2(1H)-ones.

Keywords:

FGFR receptor, Cancer metabolism, FGFR1 inhibitors, FGFR mediated signaling, cancer

Affiliation:

GVK Biosciences Pvt. Ltd.,Phase-1, Technocrats Industrial Estate, Balanagar 500037, Andhra Pradesh, India.



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