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Neurovascular Matrix Metalloproteinases and the Blood-Brain Barrier

[ Vol. 18 , Issue. 25 ]

Author(s):

Ji Hae Seo, Shuzhen Guo, Josephine Lok, Deepti Navaratna, Michael J. Whalen, Kyu-Won Kim and Eng H. Lo   Pages 3645 - 3648 ( 4 )

Abstract:


Blood-brain barrier (BBB) leakage and brain edema is a critical part of stroke pathophysiology. In this mini-review, we briefly survey the potential role of matrix metalloproteinases (MMPs) in BBB dysfunction. A large body of data in both experimental models as well as clinical patient populations suggests that MMPs may disrupt BBB permeability and interfere with cell-cell signaling in the neurovascular unit. Hence, ongoing efforts are underway to validate MMPs as potential biomarkers in stroke as well as pursue MMP blockers as therapeutic opportunities. Because BBB perturbations may also occur in neurodegeneration, MMPs and associated neurovascular unit mechanisms may also be potential targets in a broader range of CNS disorders.

Keywords:

Brain edema, neuroprotection, neurodegeneration, neurovascular unit, stroke recovery, Blood-brain barrier (BBB), matrix metalloproteinases (MMPs), BBB permeability, biomarkers, CNS disorders.

Affiliation:

Departments of Neurology, Radiology and Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.



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